![]() To translate his lab’s technologies into real-world clinical progress, Wang has built collaborations with a broad team of physicians and epidemiologists at Johns Hopkins and beyond. You have resolution even down to the single-cell level. You have precise temporal and spatial control. “With microfluidics,” Wang says, “you can control the microenvironments you want to look at. And because some of these devices have the potential to be cheap and portable, they might transform health care in low-resource countries that have few traditional hospital laboratories. Over the last decade, Wang’s lab has developed devices that might someday make it far easier for clinicians to identify infectious pathogens and to diagnose early-stage cancers. Why would anyone want to isolate such minute volumes of fluid? Because microfluidics, as Wang’s field is known, allows rapid, precise analysis of many kinds of biological processes. Others use a far smaller scale: one-trillionth of a liter. Some of his lab’s devices analyze droplets that are one-millionth of a liter. ![]() Contact us today to learn more.Tza-Huei (Jeff) Wang spends his days working with tiny droplets of fluid. Our proprietary process allows us to create precise, customized, state-of-the-art microfluidic devices based on your needs, all produced in glass. When it comes to producing the ideal microfluidic device for your specific needs, there’s only one microfluidic partner to consider: Citrogene. Microfluidics has a multitude of applications across a wide variety of industries. Citrogene: Glass Microfluidic Chip Engineers Examples are finger prick blood glucose meters for diabetes. The cartridge is then inserted into an analyzer or reader where most of the actuation, sensing and processing takes place. The microfluidic chip is usually integrated in an injection molded cartridge, cassette, or kit. This category is a middle ground between Chip-in-a-lab and Lab on a Chip. The closest could be lateral flow type platforms. Although many microfluidics chips have been called LOC, true LOCs have not emerged yet. Then control and process the flow, and give results. Such a system should drive the flow through capillary action, or inline pumps. Lab on a chipĪ true lab on a chip, is when the whole action happens in or around the microfluidic chip. Microfluidic chips could be used in pretty much any lab that uses liquid of some sort for research. The chip may be placed inside an incubator for an extended period of time for organ on chip applications. The chip may be placed under laser, magnet or piezoelectric acoustic wave makers. In this setup sometimes the microfluidic chip is placed in a regular or inverted microscope to see the action or reactions in the channels. ![]() cancer cells from regular cells. The applications of microfluidics are enormous. It could be used to separate some particles from other particles, e.g. There are thousands of ways this setup could be used. Fluid is driven into the chip and a physical, chemical, or biological experiment is set. The microfluidic chip is usually connected to a syringe pump using tubes. This is the most popular way of using a microfluidic chip. These systems fall into three main categories: Chip-in-a-lab, Lab on a chip, and integrated microfluidic chip. Microfluidic chips are often used as a part of a larger, intricate systems. We have found glass to be a durable substrate and has uses in multiple industries and benefits. At Citrogene, we have developed a proprietary manufacturing method that allows our engineers to create increasingly complex microfluidic chips with glass. Similar to microfluidic devices, many manufacturers use what is called PDMS to create microfluidic chips. What materials are used to make microfluidic chips? Microfluidic chips are the “houses” on which multiple microfluidic devices can be placed. The micro channels could be as simple as a straight line, or as complex as a network of features (chambers, channels) separated by thin walls, membranes or valves. The micro channels are usually connected to an external pump to drive nano-liters of fluid into the microchannels by means of micro-bore tubes. A microfluidic chip closely resembles a microscope slide…but microfluidic chips have micron-thin internal channels. What is a microfluidic chip?Ī microfluidic chip refers to an apparatus used in Microfluidics applications. In this post we’ll discuss what exactly is a microfluidic chip and how microfluidic chips are being used today. Microfluidics encompasses both microfluidic chips and microfluidic devices. Microfluidics has a wide range of applications across a vast swathe of industries.
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